Publications

2022

  1. Meier S, Heijman J. Commentary: EP-PINNs: Cardiac electrophysiology characterisation using physics-informed neural networks. Front Cardiovasc Med. 2022 Aug 24;9:1003652. PMID: 36093140; PMCID: PMC9448979.
  2. Cai M, Schotten U, Dobrev D, Heijman J. Atrial fibrillation substrate development before, during and after cardiac surgery: Who is to blame for late post-operative atrial fibrillation? Int J Cardiol. 2022 Oct 15;365:44-46. PMID: 35863494.
  3. Cunha PS, Laranjo S, Heijman J, Oliveira MM. The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substrates. Front Cardiovasc Med. 2022 Jul 4;9:879984. PMID: 35859594; PMCID: PMC9289204.
  4. Heijman J, Dobrev D. Molecular determinants and therapeutic potential of focal ectopic activity: more than meets the Iti. Eur Heart J. 2022 Oct 21;43(40):4208-4210. PMID: 35822877.
  5. Gawałko M, Saljic A, Li N, Abu-Taha I, Jespersen T, Linz D, Nattel S, Heijman J, Fender A, Dobrev D. Adiposity-associated atrial fibrillation: molecular determinants, mechanisms and clinical significance. Cardiovasc Res. 2022 Jun 11:cvac093. PMID: 35689487.
  6. Saljic A, Heijman J, Dobrev D. Emerging Antiarrhythmic Drugs for Atrial Fibrillation. Int J Mol Sci. 2022 Apr 7;23(8):4096. PMID: 35456912; PMCID: PMC9029767.
  7. Scheurlen C, van den Bruck JH, Filipovic K, Wörmann J, Arica Z, Erlhöfer S, Dittrich S, Heijman J, Lüker J, Steven D, Sultan A. Procedural and outcome impact of obesity in cryoballoon versus radiofrequency pulmonary vein isolation in atrial fibrillation patients. J Interv Card Electrophysiol. 2022 Apr 12. PMID: 35415815.
  8. Sutanto H, Heijman J. Integrative Computational Modeling of Cardiomyocyte Calcium Handling and Cardiac Arrhythmias: Current Status and Future Challenges. Cells. 2022 Mar 24;11(7):1090. PMID: 35406654; PMCID: PMC8997666.
  9. Colman MA, Alvarez-Lacalle E, Echebarria B, Sato D, Sutanto H, Heijman J. Multi-Scale Computational Modeling of Spatial Calcium Handling From Nanodomain to Whole-Heart: Overview and Perspectives. Front Physiol. 2022 Mar 9;13:836622. PMID: 35370783; PMCID: PMC8964409.
  10. Wiedmann F, Beyersdorf C, Zhou XB, Kraft M, Paasche A, Jávorszky N, Rinné S, Sutanto H, Büscher A, Foerster KI, Blank A, El-Battrawy I, Li X, Lang S, Tochtermann U, Kremer J, Arif R, Karck M, Decher N, van Loon G, Akin I, Borggrefe M, Kallenberger S, Heijman J, Haefeli WE, Katus HA, Schmidt C. Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy. Cardiovasc Res. 2022 Jun 22;118(7):1728-1741. PMID: 34028533.

2021

  1. Heijman J, Rahm AK, Dobrev D. Stretching the limits of antiarrhythmic drug therapy: The promise of small-conductance calcium-activated potassium channel blockers. Int J Cardiol Heart Vasc. 2021 Dec 1;37:100924. PMID: 34917752; PMCID: PMC8645440.
  2. Ravens U, Gomez AM, Heijman J, Remme CA, Dobrev D, Smith G, Volders PGA, Cerbai E, Eisner DA, Casadei B, Zaza A, Richard S, Mugelli A, Vassort G, Brown HF, Sipido KR. Edward Carmeliet (1930-2021)-channelling scientific curiosity: a tribute from the ESC Working Group on Cardiac Cellular Electrophysiology†. Cardiovasc Res. 2021 Dec 17;117(14):e171-e173. PMID: 34850866.
  3. Cluitmans MJM, Bear LR, Nguyên UC, van Rees B, Stoks J, Ter Bekke RMA, Mihl C, Heijman J, Lau KD, Vigmond E, Bayer J, Belterman CNW, Abell E, Labrousse L, Rogier J, Bernus O, Haïssaguerre M, Hassink RJ, Dubois R, Coronel R, Volders PGA. Noninvasive detection of spatiotemporal activation-repolarization interactions that prime idiopathic ventricular fibrillation. Sci Transl Med. 2021 Nov 17;13(620):eabi9317. PMID: 34788076.
  4. Lyon A, van Opbergen CJM, Delmar M, Heijman J, van Veen TAB. In silico Identification of Disrupted Myocardial Calcium Homeostasis as Proarrhythmic Trigger in Arrhythmogenic Cardiomyopathy. Front Physiol. 2021 Sep 24;12:732573. PMID: 34630150; PMCID: PMC8497808.
  5. Sutanto H, Dobrev D, Heijman J. Angiotensin Receptor-Neprilysin Inhibitor (ARNI) and Cardiac Arrhythmias. Int J Mol Sci. 2021 Aug 20;22(16):8994. PMID: 34445698; PMCID: PMC8396594.
  6. Odening KE, Gomez AM, Dobrev D, Fabritz L, Heinzel FR, Mangoni ME, Molina CE, Sacconi L, Smith G, Stengl M, Thomas D, Zaza A, Remme CA, Heijman J. ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research. Europace. 2021 Nov 8;23(11):1795-1814. PMID: 34313298.
  7. Nedios S, Lindemann F, Heijman J, Crijns HJGM, Bollmann A, Hindricks G. Atrial remodeling and atrial fibrillation recurrence after catheter ablation : Past, present, and future developments. Herz. 2021 Aug;46(4):312-317. PMID: 34223914.
  8. Wagner M, Sadek MS, Dybkova N, Mason FE, Klehr J, Firneburg R, Cachorro E, Richter K, Klapproth E, Kuenzel SR, Lorenz K, Heijman J, Dobrev D, El-Armouche A, Sossalla S, Kämmerer S. Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression. Int J Mol Sci. 2021 May 1;22(9):4816. PMID: 34062838; PMCID: PMC8125727.
  9. Vagos MR, Arevalo H, Heijman J, Schotten U, Sundnes J. A Computational Study of the Effects of Tachycardia-Induced Remodeling on Calcium Wave Propagation in Rabbit Atrial Myocytes. Front Physiol. 2021 Apr 9;12:651428. PMID: 33897459; PMCID: PMC8063103.
  10. Xenakis MN, Kapetis D, Yang Y, Gerrits MM, Heijman J, Waxman SG, Lauria G, Faber CG, Westra RL, Lindsey PJ, Smeets HJ. Hydropathicity-based prediction of pain-causing NaV1.7 variants. BMC Bioinformatics. 2021 Apr 23;22(1):212. PMID: 33892629; PMCID: PMC8063372.
  11. Heijman J, Sutanto H, Crijns HJGM, Nattel S, Trayanova NA. Computational models of atrial fibrillation: achievements, challenges, and perspectives for improving clinical care. Cardiovasc Res. 2021 Jun 16;117(7):1682-1699. PMID: 33890620; PMCID: PMC8208751.
  12. Heijman J, Hohnloser SH, Camm AJ. Antiarrhythmic drugs for atrial fibrillation: lessons from the past and opportunities for the future. Europace. 2021 Apr 10;23(23 Suppl 2):ii14-ii22. PMID: 33837753.
  13. Heijman J, Vernooy K, C van Gelder I. The road goes ever on: innovations and paradigm shifts in atrial fibrillation management. Europace. 2021 Apr 10;23(23 Suppl 2):ii1-ii3. PMID: 33837751.
  14. Heijman J, Ghossein MA, Vernooy K, Linz D. The walk of life: Remote monitoring provides insights into physical activity during a pandemic. Int J Cardiol Heart Vasc. 2021 Apr;33:100772. PMID: 33821211; PMCID: PMC8012064.
  15. van Cauteren YJM, Smulders MW, Theunissen RALJ, Gerretsen SC, Adriaans BP, Bijvoet GP, Mingels AMA, van Kuijk SMJ, Schalla S, Crijns HJGM, Kim RJ, Wildberger JE, Heijman J, Bekkers SCAM. Cardiovascular magnetic resonance accurately detects obstructive coronary artery disease in suspected non-ST elevation myocardial infarction: a sub-analysis of the CARMENTA Trial. J Cardiovasc Magn Reson. 2021 Mar 22;23(1):40. PMID: 33752696; PMCID: PMC7983380.
  16. Lyon A, van Mourik M, Cruts L, Heijman J, Bekkers SCAM, Schotten U, Crijns HJGM, Linz D, Lumens J. Both beat-to-beat changes in RR-interval and left ventricular filling time determine ventricular function during atrial fibrillation. Europace. 2021 Mar 4;23(23 Suppl 1):i21-i28. PMID: 33751072; PMCID: PMC7943365.
  17. Xenakis MN, Kapetis D, Yang Y, Heijman J, Waxman SG, Lauria G, Faber CG, Smeets HJ, Lindsey PJ, Westra RL. Non-extensitivity and criticality of atomic hydropathicity around a voltage-gated sodium channel’s pore: a modeling study. J Biol Phys. 2021 Mar;47(1):61-77. PMID: 33735400; PMCID: PMC7981368.
  18. Nedios S, Sanatkhani S, Oladosu M, Seewöster T, Richter S, Arya A, Heijman J, J G M Crijns H, Hindricks G, Bollmann A, Menon PG. Association of low-voltage areas with the regional wall deformation and the left atrial shape in patients with atrial fibrillation: A proof of concept study. Int J Cardiol Heart Vasc. 2021 Feb 26;33:100730. PMID: 33718586; PMCID: PMC7933256.
  19. Fabritz L, Crijns HJGM, Guasch E, Goette A, Häusler KG, Kotecha D, Lewalter T, Meyer C, Potpara TS, Rienstra M, Schnabel RB, Willems S, Breithardt G, Camm AJ, Chan A, Chua W, de Melis M, Dimopoulou C, Dobrev D, Easter C, Eckardt L, Haase D, Hatem S, Healey JS, Heijman J, Hohnloser SH, Huebner T, Ilyas BS, Isaacs A, Kutschka I, Leclercq C, Lip GYH, Marinelli EA, Merino JL, Mont L, Nabauer M, Oldgren J, Pürerfellner H, Ravens U, Savelieva I, Sinner MF, Sitch A, Smolnik R, Steffel J, Stein K, Stoll M, Svennberg E, Thomas D, Van Gelder IC, Vardar B, Wakili R, Wieloch M, Zeemering S, Ziegler PD, Heidbuchel H, Hindricks G, Schotten U, Kirchhof P. Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference. Europace. 2021 Mar 8;23(3):329-344. PMID: 33555020.
  20. Heijman J, Luermans JGLM, Linz D, van Gelder IC, Crijns HJGM. Risk Factors for Atrial Fibrillation Progression. Card Electrophysiol Clin. 2021 Mar;13(1):201-209. PMID: 33516398
  21. Aguilar M, Heijman J, Dobrev D, Nattel S. One Ring to Rule Them All: Continuous Monitoring of Patients With Secondary Atrial Fibrillation Points to a Unifying Underlying Mechanism. Can J Cardiol. 2021 May;37(5):686-689. PMID: 33493661.
  22. Peper J, Kownatzki-Danger D, Weninger G, Seibertz F, Pronto JRD, Sutanto H, Pacheu-Grau D, Hindmarsh R, Brandenburg S, Kohl T, Hasenfuss G, Gotthardt M, Rog-Zielinska EA, Wollnik B, Rehling P, Urlaub H, Wegener J, Heijman J, Voigt N, Cyganek L, Lenz C, Lehnart SE. Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes. Circ Res. 128(6):e102-e120. PMID: 33486968.
  23. Qi XY, Vahdati Hassani F, Hoffmann D, Xiao J, Xiong F, Villeneuve LR, Ljubojevic-Holzer S, Kamler M, Abu-Taha I, Heijman J, Bers DM, Dobrev D, Nattel S. Inositol Trisphosphate Receptors and Nuclear Calcium in Atrial Fibrillation. Circ Res. 2021 Mar 5;128(5):619-635. PMID: 33375812; PMCID: PMC8243404.
  24. Nedios S, Löbe S, Knopp H, Seewöster T, Heijman J, Crijns HJGM, Arya A, Bollmann A, Hindricks G, Dinov B (2021) Left atrial activation and asymmetric anatomical remodeling in patients with atrial fibrillation: The relation between anatomy and function. Clin Cardiol. 44(1):116-122. PMID: 33200840; PMCID: PMC7803371.
  25. Heijman J, Linz D, Schotten U (2021) Dynamics of Atrial Fibrillation Mechanisms and Comorbidities. Annu Rev Physiol. 83:83-106. PMID: 33064962.

2020

  1. Sutanto H, Heijman J (2020) Beta-Adrenergic Receptor Stimulation Modulates the Cellular Proarrhythmic Effects of Chloroquine and Azithromycin. Front Physiol. 11:587709 (IF: 3.367) – [Pubmed]
  2. Vagos MR, Arevalo H, Heijman J, Schotten U, Sundnes J (2020) A Novel Computational Model of the Rabbit Atrial Cardiomyocyte With Spatial Calcium Dynamics. Front Physiol. 11:556156 (IF: 3.367) – [Pubmed]
  3. Gómez AM, Heijman J, Remme CA (2020) The ESC Working Group Cardiac Cellular Electrophysiology. Eur Heart J. 41(46):4374-4376 (IF: 22.673) – [Pubmed]
  4. Bogossian H, Linz D, Heijman J, Bimpong-Buta NY, Bandorski D, Frommeyer G, Erkapic D, Seyfarth M, Zarse M, Crijns HJ (2020) QTc evaluation in patients with bundle branch block. Int J Cardiol Heart Vasc. 30:100636 (IF: -/-) – [Pubmed]
  5. Barrios Espinosa C, Hemels MEW, Dobrev D, Heijman J (2020) Recurrence of atrial fibrillation following non-cardiac surgery or acute illness: A common but rarely detected complication. Int J Cardiol Heart Vasc. 29:100609 (IF: -/-) – [Pubmed]
  6. Altrocchi C, de Korte T, Bernardi J, Spätjens RLHMG, Braam SR, Heijman J, Zaza A, Volders PGA (2020) Repolarization instability and arrhythmia by IKr block in single human-induced pluripotent stem cell-derived cardiomyocytes and 2D monolayers. Europace. 22(9):1431-1441 (IF: 4.045) – [Pubmed]
  7. Heijman J*, Muna AP*, Veleva T, Molina CE, Sutanto H, Tekook M, Wang Q, Abu-Taha IH, Gorka M, Künzel S, El-Armouche A, Reichenspurner H, Kamler M, Nikolaev V, Ravens U, Li N, Nattel S, Wehrens XHT, Dobrev D (2020) Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation. Circ Res. 127(8):1036-1055 (IF: 15.862) – [Pubmed]
  8. Lyon A, Dupuis LJ, Arts T, Crijns HJGM, Prinzen FW, Delhaas T, Heijman J*, Lumens J* (2020). Differentiating the effects of β-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model. Am J Physiol Heart Circ Physiol. 319(3):H519-H530 (IF: X.XXX) – [Pubmed]
  9. Vranken NPA, Pustjens TFS, Kolkman E, Hermanides RS, Bekkers SCAM, Smulders MW, van Cauteren YJM, Heijman J, Rasoul S, Ottervanger JP, van ‘t Hof AWJ (2020) MINOCA: The caveat of absence of coronary obstruction in myocardial infarction. Int J Cardiol Heart Vasc. 29:100572 (IF: -/-) – [Pubmed]
  10. Sutanto H, Cluitmans M, Dobrev D, Volders PGA, Bébarová M, Heijman J (2020) Acute effects of alcohol on cardiac electrophysiology and arrhythmogenesis: Insights from multiscale in silico analyses. J Mol Cell Cardiol. Epub ahead of print. (IF: 4.133) – [Pubmed]
  11. Nattel S, Heijman J, Zhou L, Dobrev D (2020) Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy; A translational perspective. Circ Res. 127(1):51-72 (IF: 15.862) – [Pubmed]
  12. Sultan A, Wörmann J, Lüker J, V D Bruck J-, Plenge T, Rudolph V, Klinke A, Heijman J, Mollenhauer M, Ravekes T, Baldus S, Steven D (2020) Significance of myeloperoxidase plasma levels as a predictor for cardiac resynchronization therapy response. Clin Res Cardiol. Epub ahead of print. (IF: 5.268) – [Pubmed]
  13. Xenakis MN, Kapetis D, Yang Y, Heijman J, Waxman SG, Lauria G, Faber CG, Smeets HJ, Westra RL, Lindsey PJ (2020) Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution. Proteins. Epub ahead of print. (IF: 2.828) – [Pubmed]
  14. Linz D, Linz B, Heijman J (2020) Sleep Apnea, Intermittent Hypoxemia, and Effects on Ischemic Myocardial Damage: Friend or Foe? Can J Cardiol. 36(6):809-812. (IF: 5.592) – [Pubmed]
  15. Sutanto H, Lyon A, Lumens J, Schotten U, Dobrev D, Heijman J (2020) Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies. Prog Biophys Mol Biol. S0079-6107(20)30016-X. Epub ahead of print (IF: 2.703) – [Pubmed]
  16. Coopmans C, Zhou TL, Henry RMA, Heijman J, Schaper NC, Koster A, Schram MT, van der Kallen CJH, Wesselius A, den Engelsman RJA, Crijns HJGM, Stehouwer CDA (2020) Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study. Diabetes Care. 43(5):1126-1133. (IF: 15.300) – [Pubmed]
  17. Kostopoulou A, Zeljko HM, Bogossian H, Ciudin R, Costa F, Heijman J, Kochhaeuser S, Manola S, Scherr D, Sohal M, Wakili R, Wolf M, Irfan G; on the behalf of the DAS-CAM participants 2017–2018 (2020) Atrial fibrillation-related stroke in women: evidence and inequalities in epidemiology, mechanisms, clinical presentation and management. Clin Cardiol. 43:14-23. (IF: 2.455) – [Pubmed]

2019

  1. Sutanto, H, Heijman J (2019) The Role of Calcium in the Human Heart: With Great Power Comes Great Responsibility Front Young Minds. May 10;7:65. (IF: -/-) – [Link]
  2. Heijman J, Dobrev D (2019) Bayesian network analyses in atrial fibrillation – A path to better therapies? Int J Cardiol Heart Vasc. Mar 4;22:210-211. (IF: -/-) – [Pubmed]
  3. Grandi E, Dobrev D, Heijman J (2019) Computational modeling: What does it tell us about atrial fibrillation therapy? Int J Cardiol. Jan 25, Epub ahead of print. (IF: 4.034) – [Pubmed]
  4. Dobrev D, Aguilar M, Heijman J, Guichard JB, Nattel S (2019) Postoperative atrial fibrillation: mechanisms, manifestations and management. Nat Rev Cardiol. Feb 21, Epub ahead of print. (IF: 14.299) – [Pubmed]
  5. van Mourik MJW, Zaar DVJ, Smulders MW, Heijman J, Lumens J, Dokter JE, Lima Passos V, Schalla S, Knackstedt C, Schummers G, Gjesdal O, Edvardsen T, Bekkers SCAM (2019) Adding Speckle-Tracking Echocardiography to Visual Assessment of Systolic Wall Motion Abnormalities Improves the Detection of Myocardial Infarction. J Am Soc Echocardiogr. Jan;32(1):65-73. (IF: 6.827) – [Pubmed]
  6. Thomas D, Christ T, Fabritz L, Goette A, Hammwöhner M, Heijman J, Kockskämper J, Linz D, Odening KE, Schweizer PA, Wakili R, Voigt N. (2019) German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management Clin Res Cardiol. Oct 10 2018; Epub ahead of print. (IF: 4.455) – [Pubmed]

2018

  1. Nguyên UC, Potse M, Vernooy K, Mafi-Rad M, Heijman J, Caputo ML, Conte G, Regoli F, Krause R, Moccetti T, Auricchio A, Prinzen FW, Maffessanti F (2018) A left bundle branch block activation sequence and ventricular pacing influence voltage amplitudes: an in vivo and in silico study. Europace. Nov 1;20(suppl_3):iii77-iii86. (IF: 5.231) – [Pubmed]
  2. Molina CE, Abu-Taha IH, Wang Q, Roselló-Díez E, Kamler M, Nattel S, Ravens U, Wehrens XHT, Hove-Madsen L, Heijman J, Dobrev D (2018) Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation. Front Physiol. Oct 9;9:1383. (IF: 3.394) – [Pubmed]
  3. Sutanto H, Dobrev D, Heijman J (2018) Resveratrol: an effective pharmacological agent to prevent inflammation-induced atrial fibrillation? Naunyn Schmiedebergs Arch Pharmacol. Nov;391(11):1163-1167. (IF: 2.376) – [Pubmed]
  4. Clerx M, Heijman J, Collins P, Volders PGA (2018) Predicting changes to INa from missense mutations in human SCN5A. Sci Rep. Aug 24;8(1):12797. (IF: 4.122) – [Pubmed]
  5. Sutanto H, van Sloun B, Schönleitner P, van Zandvoort MAMJ, Antoons G, Heijman J (2018) The Subcellular Distribution of Ryanodine Receptors and L-type Ca2+ Channels Modulates Ca2+-transient Properties and Spontaneous Ca2+-release Events in Atrial Cardiomyocytes. Front Physiol. Aug 14;9:1108. (IF: 3.394) – [Pubmed]
  6. Heijman J, Dobrev D, Crijns HJGM (2018) Electrocardiographic characteristics associated with atrial fibrillation – What do they tell us? Int J Cardiol. 266:143-144. (IF: 6.189) – [Pubmed]
  7. Heijman J, Guichard JB, Dobrev D, Nattel S (2018) Translational challenges in atrial fibrillation. Circ Res. 122(5):752-773. (IF: 11.551) – [Pubmed]
  8. Heijman J, Kirchner D, Kunze F, Chrétien EM, Michel-Reher MB, Voigt N, Knaut M, Michel MC, Ravens U, Dobrev D (2018) Muscarinic type-1 receptors contribute to IK,ACh in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation. Int J Cardiol. 255:61-68. (IF: 6.189) – [Pubmed]
  9. Heijman J, Dobrev D (2018) Ion channels as part of macromolecular multiprotein complexes : Clinical significance. Herzschrittmacherther Elektrophysiol. 29(1):30-35. (IF: -/-) – [Pubmed]
  10. Abu-Taha IH, Heijman J, Feng Y, Vettel C, Dobrev D, Wieland T (2018) Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update.
    Lab Invest. 98(2):190-197. (IF: 4.857) – [Pubmed]

2017

  1. Heijman J, Dobrev D (2017) Inhibition of Small-Conductance Ca2+-Activated K+ Channels: The Long-Awaited Breakthrough for Antiarrhythmic Drug Therapy of Atrial Fibrillation? Circ Arrhythm Electrophysiol. 10(10). pii: e005776 (IF: 5.410)- [Pubmed]
  2. Heijman J, Dobrev D, Crijns HJGM (2017) Targeting supraventricular ectopic complexes: Which approach should be used and how does it affect atrial fibrillation? Int J Cardiol. 244:202-203. (IF: 6.189)- [Pubmed]
  3. Heijman J, Ghezelbash S, Dobrev D (2017) Investigational antiarrhythmic agents: promising drugs in early clinical development. Expert Opin Investig Drugs. Epub Jul 10th (IF: 4.030) – [Pubmed]
  4. Tomek J, Rodriguez B, Bub G, Heijman J (2017) β-adrenergic receptor stimulation inhibits proarrhythmic alternans in post-infarction border zone cardiomyocytes: a computational analysis. Am J Physiol Heart Circ Physiol. Epub May 26th (IF: 3.840) – [Pubmed]
  5. Neef S, Heijman J, Otte K, Dewenter M, Saadatmand AR, Meyer-Roxlau S, Antos CL, Backs J, Dobrev D, Wagner M, Maier LS, El-Armouche A (2017) Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity. Naunyn Schmiedebergs Arch Pharmacol. Epub Apr 27th (IF: 2.376) – [Pubmed]
  6. Heijman J, Ghezelbash S, Wehrens XH, Dobrev D (2017) Serine/Threonine Phosphatases in Atrial Fibrillation. J Mol Cell Cardiol, 103:110-120. (IF: 4.874) – [Pubmed]
  7. Schmidt C, Wiedmann F, Zhou XB, Heijman J, Voigt N, Ratte A, Lang S, Kallenberger SM, Campana C, Weymann A, De Simone R, Szabo G, Ruhparwar A, Kallenbach K, Karck M, Ehrlich JR, Baczkó I, Borggrefe M, Ravens U, Dobrev D, Katus HA, Thomas D (2017) Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy. Eur Heart J. 38(22): 1764-1774 (IF: 15.064) – [Pubmed]
  8. Abu-Taha IH*, Heijman J*, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D#, Wieland T# (2017) Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Circulation, 135(9): 881-897. *equally contributing first authors, #co-senior and co-corresponding authors (IF: 17.047) – [Pubmed]
  9. Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V (2017) Potassium channels in the heart: structure, function and regulation. J Physiol, 595(7): 2209-2228. (IF: 4.731) – [Pubmed]
  10. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM (2017) Potassium currents in the heart: Functional roles in repolarization, arrhythmia and therapeutics. J Physiol, 595(7): 2229-2252. (IF: 4.731) – [Pubmed]

2016

  1. Molina CE*, Heijman J*, Dobrev D (2016) Differences in left versus right ventricular electrophysiological properties in cardiac dysfunction and arrhythmogenesis. Arrhythm Electrophysiol Rev, 5(1): 14-9. *equally contributed first authors (IF: -/-) – [Pubmed]
  2. Heijman J, Dobrev D (2016) Challenges to the translation of basic science findings to atrial fibrillation therapies. Future Cardiol, 12(3): 251-4. (IF: -/-) – [Pubmed]
  3. Heijman J*, Algalarrondo V*, Voigt N, Melka J, Wehrens XH, Dobrev D, Nattel S (2016) The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis. Cardiovasc Res, 109(4): 467-79. *equally contributed first authors (IF: 5.465) – [Pubmed]
  4. Heijman J, Schirmer I, Dobrev D (2016) The multiple proarrhythmic roles of cardiac calcium-handling abnormalities: triggered activity, conduction abnormalities, beat-to-beat variability and adverse remodeling. Europace, 18(10): 1452-1455. (IF: 4.021) – [Pubmed]
  5. Heijman J, Erfanian Abdoust P, Voigt N, Nattel S, Dobrev D (2016) Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation. J Physiol, 594(3): 537-53 (IF: 4.731) – [Pubmed]

2015

  1. Heijman J, Crijns HJGM (2015) T-wave right slope provides a new angle in the prediction of drug-induced ventricular arrhythmias. Cardiovasc Drugs Ther, 29(5):411-413. (IF: 3.189) – [Pubmed]
  2. Voigt N, Heijman J, Dobrev D (2015) New antiarrhythmic targets in atrial fibrillation. Future Cardiol, 11(6):645-54. (IF: -/-) – [Pubmed]
  3. Heijman J, Dobrev D (2015) Irregular Rhythm and Atrial Metabolism Are Key for the Evolution of Proarrhythmic Atrial Remodeling in Atrial Fibrillation. Basic Res Cardiol, 110(4): 41. (IF: 6.008) – [Pubmed]
  4. Schmidt C, Wiedmann F, Voigt N, Zhou XB, Heijman J, Lang S, Albert V, Kallenberger S, Ruhparwar A, Szabó G, Kallenbach K, Karck M, Borggrefe M, Biliczki P, Ehrlich JR, Baczkó I, Lugenbiel P, Schweizer PA, Donner BC, Katus HA, Dobrev D, Thomas D (2015) Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients with Chronic Atrial Fibrillation Circulation, 132(2): 82-92. (IF: 17.047) – [Pubmed]
  5. Heijman J, Heusch G, Dobrev D (2015) Tools to keep the clock ticking: molecular approaches to treat sinus node dysfunction. Cardiology, 132(1): 45-48. (IF: 1.994) – [Pubmed]
  6. Heijman J*, Voigt N*, Ghezelbash S, Schirmer I, Dobrev D (2015) Calcium handling abnormalities as a target for atrial fibrillation therapeutics: How close to clinical implementation? J Cardiovasc Pharmacol, 66(6):515-22. *equally contributed first authors (IF: 2.462) – [Pubmed]

2014

  1. Heijman J, Dobrev D (2014) Rat engineered heart tissue – a novel tool in the safety pharmacology toolkit? Basic Res Cardiol, 109(6): 437. (IF: 6.008) – [Pubmed]
  2. Spätjens RLHMG, Bébarová M, Seyen SRM, Lentink V, Jongbloed RJ, Arens YHJM, Heijman J, Volders PGA (2014) Long-QT mutation p.K557E Kv7.1: dominant-negative suppression of IKs, but preserved cAMP-dependent upregulation. Cardiovasc Res, 104(1): 216-225. (IF: 5.465) – [Pubmed]
  3. Heijman J, Voigt N, Wehrens XHT, Dobrev D (2014) Calcium dysregulation in atrial fibrillation: the role of CaMKII. Front Pharmacol, 5: 30. (IF: 4.418) – [Pubmed]
  4. Heijman J*, Voigt N*, Nattel S, Dobrev D (2014) Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance and Progression. Circ Res, 114(9): 1483-1499. *equally contributed first authors (IF: 11.551) – [Pubmed]
  5. Voigt N, Heijman J, Dobrev D (2014) Kardiovaskuläre Pharmakotherapie: Risiken und Nebenwirkungen. Herz, 39(2): 227–24. (IF: 0.751) – [Pubmed]
  6. Heijman J, Voigt N, Carlsson LG, Dobrev D (2014) Cardiac Safety Assays. Curr Opin Pharmacol, 15: 16-21. (IF: 4.769) – [Pubmed]
  7. Voigt N*, Heijman J*, Wang Q, Chiang DY, Li N, Karck M, Wehrens XHT, Nattel S, Dobrev D (2014) Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients with Paroxysmal Atrial Fibrillation. Circulation, 129(2): 145-156. *equally contributed first authors (IF: 17.047) – [Pubmed]
  8. Voigt N, Abu-Taha I, Heijman J, Dobrev D (2014) Constitutive activity of the acetylcholine-activated potassium current IK,ACh in cardiomyocytes. Adv Pharmacol. 2014;70:393-409 (IF: -/-) – [Pubmed]

2013

  1. Heijman J*, Dewenter M*, El-Armouche A, Dobrev D (2013) Function and regulation of Serine/Threonine phosphatases in the healthy and diseased heart. J Mol Cell Cardiol, 64C:90-98. (IF: 4.874)
  2. Heijman J, Heusch G, Dobrev D (2013) Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation. Clin Med Insights: Cardiol, 7:127-140. (IF: -/-)
  3. Heijman J, Voigt N, Abu-Taha IH, Dobrev D (2013) Rhythm control of atrial fibrillation in heart failure. Heart Fail Clin, 9(4):407-415. (IF: 1.764)
  4. Heijman J, Zaza A, Johnson DM, Rudy Y, Peeters RLM, Volders PGA, Westra RL (2013) Determinants of beat-to-beat variability of repolarization duration in the canine ventricular myocyte: a computational analysis. PLoS Comput Biol, 9(8):e1003202. (IF: 4.587)
  5. Heijman J, Dobrev D (2013) KCNQ1 autoantibodies: another way to regulate IKs. Cardiovasc Res, 98(3):329-331. (IF: 5.465)
  6. Heijman J, Dobrev D (2013) Pleiotropic actions of amiodarone: still puzzling after half a century. Naunyn Schmiedeberg’s Arch Pharmacol, 386(7):571-574. (IF: 2.376)
  7. Voigt N*, Heijman J*, Trausch A, Mintert-Jancke E, Pott L, Ravens U, Dobrev D (2013) Impaired Na+-dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic atrial fibrillation. J Mol Cell Cardiol, 53(3):142-152. (IF: 4.874)
  8. Tsuji Y*, Heijman J*, Nattel S, Dobrev D (2013) Electrical storm: recent pathophysiological insights and therapeutic consequences. Basic Res Cardiol, 108(2): 336-345. (IF: 6.008)
  9. Johnson DM*, Heijman J*, Bode EF, Greensmith DJ, Van der Linde H, Abi-Gerges N, Eisner D, Trafford AW, Volders PGA (2013) Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation. Circ Res, 112(2):246-256. (IF: 11.551)
  10. Heijman J, Wehrens XHT, Dobrev D (2013) Atrial arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia – is there a mechanistic link between sarcoplasmic reticulum Ca2+ leak and reentry? Acta Physiol (Oxf.), 207(2):208-211. (IF: 4.066)
  11. Heijman J, Voigt N, Dobrev D (2013) New directions in antiarrhythmic drug therapy for atrial fibrillation. Future Cardiol, 9(1):71-88. (IF: -/-)